By Professor and Chair Dr Yunbo Li
This can be a ebook that takes a distinct method of integrating wisdom in antioxidants from necessities to advances, and from simple study to medical purposes. This booklet offers medical details on antioxidants in an organised, cogent, and in-depth demeanour. The constant structure of writing, the full-colour illustrations, and the great checklist of references make the e-book available and fascinating. in addition to its worth as a textbook for undergraduate and graduate scholars in existence technological know-how, "Antioxidants in Biology and drugs" may also be an invaluable reference for biomedical learn scientists, clinicians, and different wellbeing and fitness execs.
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Additional resources for Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications
Gene therapy with the use of antioxidant genes is emerging as a promising approach for select disease conditions and is an especially lucrative option for patient groups not suitable for conventional therapies . However, this approach is much limited in human studies due to safety concerns. 2. Genetic Variation Studies The discovery in 1993 of the Cu,ZnSOD mutations in familial amyotrophic lateral sclerosis, a fatal, adult-onset neurodegenerative disease primarily affecting motor neurons, has attracted broad attention on the biological role of SODs in human disorders .
The increased production of antioxidants helps detoxify the ROS/RNS and may even render cells more resistant to higher levels of ROS/RNS. Thus, Nrf2-dependent upregulation of antioxidants by moderate levels of ROS/RNS can be viewed as an adaptive response to oxidative stress. Two potential mechanisms have been proposed to explain the dissociation of Nrf2 from Keap1 under stress conditions, which are summarized below [10, 11]. Oxidation of cysteine residues of Keap1: Keap1 is a cysteine-rich protein, and the cysteine residues may serve as redox sensors for ROS/RNS or chemical inducers.
Chem. 2008;283:33554-33562. Sankaranarayanan K, Jaiswal AK. Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. J. Biol. Chem. 2004;279:50810-50817. Yang H, Magilnick N, Lee C, Kalmaz D, Ou X, Chan JY, et al. Nrf1 and Nrf2 regulate 30            Antioxidants in Biology and Medicine rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications by Professor and Chair Dr Yunbo Li