By Charles H. Nightingale, Paul G. Ambrose, George L. Drusano, Takeo Murakawa
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Extra info for Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 2nd Edition
Source: From Ref. 17. 26 Mouton et al. the unbound fraction of the drug of around 100 for infections caused by gramnegative rods and 30 to 40 for Streptococcus pneumoniae, and that these values are consistent within the class of quinolones. Since the objective of treating patients is to treat them optimally, this translates in, when administering antimicrobials to a patient to treat an infection, the AUC of the antimicrobial administered in relation to the MIC of the microorganism causing the infection, a value of at least 100 for gram-negative rods.
Report from “the Norwegian Working Group on Antibiotics”. Scand J Infect Dis Suppl 1997; 103:1–36. Deutsches Institut fur Normung. DIN 58 940-10, Criteria for the Categorization of the In-Vitro Activity of Antimicrobial Agents. Beuth Verlag: Deutsches Institut fur Normung, 1990. Kahlmeter G, Brown DF, Goldstein FW, et al. European Committee on Antimicrobial Susceptibility Testing (EUCAST) technical notes on antimicrobial susceptibility testing. Clin Microbiol Infect 2006; 12(6):501–503. org Vogelman B, Craig WA.
Compared the results of MCSs of ceftazidime for three different populations: healthy volunteers, patients with cystic fibrosis, and intensive-care patients. Although there were differences at the extremes of the distribution, the general conclusion was similar for the patients and the volunteers. THE USE OF CART® ANALYSIS AND OTHER TOOLS TO DETERMINE THE PI SUSCEPTIBILITY BREAKPOINT VALUE The rate at which we are accumulating knowledge from analyses of PK–PD data derived from well-controlled clinical studies is accelerating.
Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 2nd Edition by Charles H. Nightingale, Paul G. Ambrose, George L. Drusano, Takeo Murakawa