New PDF release: Aerobatic teams

By Richard Ward

ISBN-10: 0850450462

ISBN-13: 9780850450460

ISBN-10: 085045090X

ISBN-13: 9780850450903

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Peschanski, P. Aebischer and P. Hantraye, Hum. Gene. , 2000, 11, 1177. 69. J. Ye, L. Cao, R. Cui, A. Huang, Z. Yan, C. Lu and C. , 2004, 997, 30. 70. G. J. Ho, R. Drego, E. Hakimian and E. Masliah, Curr. Drug. Targets. Inflamm. Allergy, 2005, 4, 247. 71. D. Morgan, M. N. Gordon, J. Tan, D. Wilcock and A. M. Rojiani, J. Neuropathol. Exp. , 2005, 64, 743. 72. N. Kaur, B. Lu, R. K. Monroe, S. M. Ward and S. W. Halvorsen, J. , 2005, 92, 1521. 73. H. Chen, Y. S. Fu and J. W. Guo, Hippocampus, 2004, 14.

5 PDEs as Targets to Impact Synaptic Plasticity It is clear from the brief summary presented above that both cAMP and cGMP signalling cascades play multiple roles in synaptic plasticity that occur over time and in different spatial compartments in response to changing synaptic activity. This suggests that the PDEs, as key regulators of the cAMP and cGMP signalling cascades, bear investigation as a means to modulate synaptic plasticity. 15 Given that cyclic nucleotide signalling is highly compartmentalised, it is likely that different PDE isoforms regulate distinct aspects of synaptic plasticity.

Tham, A. Nordberg, F. E. Grissom, C. Carlsson-Skwirut, M. Viitanen and V. R. Sara, J. Neural. Transm. Park. Dis. Dement. , 1993, 5, 165. 82. R. Riikonen, J. Child. , 2003, 18, 693. 83. R. Vanhala, U. Turpeinen and R. Riikonen, Dev. Med. Child. , 2001, 43, 614. 84. G. Anneren, T. Tuvemo, C. Carlsson-Skwirut, T. Lonnerholm, P. Bang, V. R. Sara and J. Gustafsson, Arch. Dis. , 1999, 80, 334. 85. L. Ragusa, M. R. Valetto, C. Proto, A. Alberti, C. Romano, A. Rossodivita, G. Corneli, C. Baffoni, F. Lanfranco, G.

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Aerobatic teams by Richard Ward


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